"Warning that the powerful poisons can endanger some dogs and cats, the U.S. Environmental Protection Agency will require new instructions and labeling for on-spot flea products. The EPA began investigating the products, which include the popular Frontline and Advantage brands, after a sharp rise in the number of dogs and cats reported to be sick. The investigation concluded that certain pets – small dogs between 10 and 20 pounds – are most susceptible to the problems, which include rashes, vomiting, diarrhea and seizures. Incidents reported by consumers rose from 28,895 in 2007 to 44,263 in 2008, an increase of 53 percent. Most of the problems were minor, such as skin rashes, but about 600 dogs and cats died in incidents reported in 2008. "